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The cloud backup and device sync service SugarSync conflicts with Photo Supreme. Photo Supreme will not boot up if SugarSync is running. However, If you quit SugarSync, Photo Supreme will start normally, and afterwards SugarSync may be started with no further problems. I'm running a 21.5" mid 2011 iMac, OS X v. 10.10.5, Photo Supreme build 188.8.131.522.